Efficacy of Donepezil in Improving Cognitive Impairment Induced by Electroconvulsive Therapy in Patients with Mood Disorders: A Randomized, Double-blind, Placebo-Controlled Trial
| Author | Elham Zarean | en |
| Author | Morteza Sedehi | en |
| Author | Yalda Heshmati | en |
| Orcid | Elham Zarean [0000-0001-7294-6709] | en |
| Orcid | Morteza Sedehi [0000-0003-4403-1709] | en |
| Issued Date | 2021-09-30 | en |
| Abstract | Background: Electroconvulsive therapy (ECT) is an effective strategy in the treatment of mood disorders; however, it is associated with some cognitive complications. Objectives: This study aimed to evaluate the efficacy of donepezil as an acetylcholinesterase inhibitor in improving cognitive impairment induced by ECT in mood disorder patients. Methods: Ninety-six mood disorder patients were randomly assigned to the donepezil (5mg/day) or placebo groups. The Persian versions of the Mini-Mental Status examination (MMSE) and Addenbrooke’s Cognitive Examination Revised (ACE-R) were used to evaluate cognitive performance before the first ECT session, after the fourth ECT session, and four weeks after the last ECT session. Results: The mean scores of MMSE and ACE-R revealed significant improvement in the donepezil group over time (P < 0.001). All ACE-R subscales increased significantly following the intervention implementation in the donepezil group (P < 0.001). Furthermore, the donepezil group reported no remarkable complications and completed the study. Conclusions: Donepezil co-administration with ECT may improve the ECT-induced cognitive disturbances. | en |
| DOI | https://doi.org/10.5812/ijpbs.107598 | en |
| Keyword | Clinical Trial | en |
| Keyword | Cognitive Dysfunction | en |
| Keyword | Donepezil, Electroconvulsive Therapy | en |
| Keyword | Mood Disorders | en |
| Publisher | Brieflands | en |
| Title | Efficacy of Donepezil in Improving Cognitive Impairment Induced by Electroconvulsive Therapy in Patients with Mood Disorders: A Randomized, Double-blind, Placebo-Controlled Trial | en |
| Type | Research Article | en |
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