The Relationship Between Polymorphisms of Glutathione S-Transferase (GSTM1, GSTT1) Gene and Type 2 Diabetes Mellitus in Western Iran
| Author | Fatemeh Kazemisafa | en |
| Author | Kamalaldin Jadidian | en |
| Author | Zohreh Rahimi | en |
| Author | Hamid Nomani | en |
| Author | Azadeh Ghanbari | en |
| Author | Gelareh Saeb | en |
| Author | Arash Alikhani | en |
| Orcid | Fatemeh Kazemisafa [0000-0002-5130-6769] | en |
| Orcid | Zohreh Rahimi [0000-0001-7589-3307] | en |
| Issued Date | 2018-12-31 | en |
| Abstract | Background: Diabetes is a chronic metabolic disorder that causes many complications in the body. Oxidative free radicals affect human beta cells. Glutathione S-transferases (GSTs) can deactivate substances formed in oxidative stress. Objectives: The present study was conducted to examine the relationship between GSTs polymorphisms and type 2 diabetes mellitus (T2DM), and to investigate the presence of GSTM1 and T1 genotypes in 176 T2DM patients and 174 healthy cases as controls. Methods: Multiplex PCR was used to confirm the presence or absence of GSTT1 and M1 genotypes. Conclusions: The obtained results indicated that the polymorphism of GSTM1 and GSTT1 does not affect the prevalence of T2DM in the study population. | en |
| DOI | https://doi.org/10.5812/jkums.85833 | en |
| Keyword | Glutathione S-Transferase | en |
| Keyword | Genetic Polymorphism | en |
| Keyword | Oxidative Stress | en |
| Keyword | T2DM | en |
| Publisher | Brieflands | en |
| Title | The Relationship Between Polymorphisms of Glutathione S-Transferase (GSTM1, GSTT1) Gene and Type 2 Diabetes Mellitus in Western Iran | en |
| Type | Research Article | en |
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