Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy
| Author | Rabab Mohamed Mohamed | en |
| Author | Ashraf Elsayed Elgahrib Abdalla | en |
| Author | Mohsen M. Eissa | en |
| Author | Reda Khalil Abdelrahman | en |
| Author | Mohamed Galal Flefel | en |
| Author | Asmaa Abdelbadie | en |
| Author | Jehan Mohammad Ezzat Hamed Darwish | en |
| Orcid | Ashraf Elsayed Elgahrib Abdalla [0000-0001-5743-9549] | en |
| Orcid | Mohsen M. Eissa [0009-0007-9061-1399] | en |
| Orcid | Reda Khalil Abdelrahman [0009-0006-7137-7421] | en |
| Orcid | Mohamed Galal Flefel [0000-0002-0124-730X] | en |
| Issued Date | 2025-02-28 | en |
| Abstract | Background: Propofol is commonly used for sedation during colonoscopy but often requires high doses. Objectives: This study aimed to compare the outcomes of propofol alone versus propofol combined with clonidine for colonoscopy sedation. Methods: In this randomized, double-blind controlled trial, 60 adult patients scheduled for elective colonoscopy were enrolled. Patients were divided into two groups: Group 1 (G1) received propofol alone, while group 2 (G2) received propofol plus 2 μg/kg clonidine intravenously over 10 minutes. Propofol infusion was initiated at 25 - 75 μg/kg/min IV for the first 10 - 15 minutes, then titrated to 25 - 50 μg/kg/min based on clinical response. Results: Sedation onset was significantly faster in G2 than in G1 (P = 0.001). The total propofol requirement was 22% lower in G2 (P = 0.001). Heart rate (HR) and mean arterial pressure (MAP) were significantly lower in G2 at induction and at the end of the procedure (P < 0.05). Patient satisfaction scores were higher in G2 (P = 0.042). The observer's assessment of alertness/sedation (OAA/S) score after induction was lower in G2 (P = 0.015), indicating deeper sedation. However, Aldrete scores in the post-anesthesia care unit (PACU) were lower in G2 (P = 0.001), suggesting a slower recovery. Conclusions: The addition of clonidine to propofol for colonoscopy sedation led to faster sedation onset, reduced propofol requirements, improved patient satisfaction, and deeper sedation, but with potentially prolonged recovery times. | en |
| DOI | https://doi.org/10.5812/aapm-156833 | en |
| Keyword | Colonoscopy | en |
| Keyword | Sedation | en |
| Keyword | Propofol | en |
| Keyword | Clonidine | en |
| Keyword | Patient Satisfaction | en |
| Publisher | Brieflands | en |
| Title | Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy | en |
| Type | Research Article | en |
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