Effect of Rapid Changes of Light/Dark Cycle on Cholinesterase Activity in the Cerebellum and Prefrontal Cortex of Rats
| Author | Mohammad Reza Mirzaii-Dizgah | en |
| Author | Iraj Mirzaii-Dizgah | en |
| Author | Hamzeh Shahali | en |
| Author | Abbas Nourmohammadi | en |
| Orcid | Mohammad Reza Mirzaii-Dizgah [0000-0002-0587-0182] | en |
| Orcid | Iraj Mirzaii-Dizgah [0000-0002-0050-4191] | en |
| Issued Date | 2024-03-31 | en |
| Abstract | Background: Spaceflight poses unique physiological stressors, including circadian rhythm disruption, which can impact astronaut health and brain function. Objectives: This study investigated the effects of rapid day/night changes on cholinesterase activity in the rats' cerebellum and prefrontal cortex. Methods: Rats were divided into 2 groups (n = 8 per group): Control and circadian disruption with a 45-minute light/45-minute dark cycle. After 14 days of intervention, the cerebellum and prefrontal cortex were harvested from each rat. The samples were washed in ice-cold normal saline solution, weighed, homogenized in phosphate buffer using 1 ml of buffer per 100 mg of tissue, and centrifuged. Moreover, the supernatants were used for the measurement of cholinesterase activity by the photometric method. Results: Mean cholinesterase activity was significantly lower in rats exposed to circadian disruption than in the control group (P < 0.05). Conclusions: It seems that cholinesterase activity in rats' cerebellum and prefrontal cortex reduces following exposure to rapid light/dark rhythm. | en |
| DOI | https://doi.org/10.5812/amh-145088 | en |
| URI | https://brieflands.com/journals/amhsr/articles/145088 | en |
| Keyword | Circadian Disruption | en |
| Keyword | Cholinesterase | en |
| Keyword | Cerebellum | en |
| Keyword | Prefrontal Cortex | en |
| Publisher | Brieflands | en |
| Title | Effect of Rapid Changes of Light/Dark Cycle on Cholinesterase Activity in the Cerebellum and Prefrontal Cortex of Rats | en |
| Type | Research Article | en |
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