Reduced PG1 Gene Expression in Gastric Cancer Tissues: Implications for Early Diagnosis
| Author | Yousef Paridar | en |
| Author | Homa Hosseinpour | en |
| Author | Maysam Mard-Soltani | en |
| Author | Neda Shakerian | en |
| Author | Somayeh Pouriamehr | en |
| Author | Davood Alinezhad Dezfuli | en |
| Orcid | Yousef Paridar [0000-0001-9727-4048] | en |
| Orcid | Maysam Mard-Soltani [0000-0002-9473-2901] | en |
| Orcid | Neda Shakerian [0000-0001-9822-8561] | en |
| Accessioned Date | 2026-07-14T18:32:05Z | |
| Issued Date | 2025-06-30 | en |
| Abstract | Background: Gastric cancer remains a significant health burden, particularly in Iran, where its prevalence is notably higher than the global average. Early detection is crucial for improving patient outcomes, highlighting the need for accessible diagnostic tools. Objective: This study aimed to investigate molecular changes in pepsinogen 1 (PG1) in healthy tissue and in patients with gastric cancer. Methods: We investigated PG1 gene expression in gastric tissue samples from 60 patients with gastric cancer and healthy controls using quantitative real-time PCR (qRT-PCR). Statistical analysis was used to compare PG1 expression between groups. Results: PG1 gene expression was significantly lower in gastric cancer tissues than in healthy controls (P < 0.05). Conclusions: This study demonstrated significant downregulation of PG1 gene expression in gastric cancer tissue. These findings support the potential utility of PG1 as a biomarker for gastric cancer diagnosis. Further research is warranted to confirm its clinical application. | en |
| DOI | https://doi.org/10.69107/jai-156496 | en |
| URI | https://brieflands.com/journals/jai/articles/156496 | en |
| URI | https://repository.brieflands.com/handle/123456789/68013 | |
| Keyword | Gastric Cancer | en |
| Keyword | Pepsinogen 1 (PG1) | en |
| Keyword | RT-PCR | en |
| Keyword | Gene Expression | en |
| Publisher | Brieflands | en |
| Title | Reduced PG1 Gene Expression in Gastric Cancer Tissues: Implications for Early Diagnosis | en |
| Type | Research Article | en |
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