Programmable Pump for Intrathecal Morphine Delivery to Cisterna Magna: Clinical Implications in Novel Management of Refractory Pain Above Middle Thoracic Vertebrae Level Utilizing a Prospective Trial Protocol and Review
| Author | Chang Sun | en |
| Author | Yu-Tong Wang | en |
| Author | Yu-Jie Dai | en |
| Author | Zhi-Hui Liu | en |
| Author | Jing Yang | en |
| Author | Zhu-Qiang Cheng | en |
| Author | Dao-Song Dong | en |
| Author | Cheng-Fu Wang | en |
| Author | Guo-Li Zhao | en |
| Author | Gui-Jun Lu | en |
| Author | Tao Song | en |
| Author | Yi Jin | en |
| Author | Alan D. Kaye | en |
| Author | Farnad Imani | en |
| Author | Kambiz Sadegi | en |
| Author | Li-Li Sun | en |
| Author | Yong-Hai Sun | en |
| Orcid | Alan D. Kaye [0000-0003-2464-0187] | en |
| Orcid | Farnad Imani [0000-0003-0814-0772] | en |
| Orcid | Kambiz Sadegi [0000-0002-0221-5799] | en |
| Issued Date | 2021-06-30 | en |
| Abstract | Background: The cisterna Intrathecal Drug Delivery system (IDDS) with morphine has proven to be effective in treating refractory cancer pain above the middle thoracic vertebrae level in some countries. However, it has not been fully investigated in others. We designed the current project to investigate the efficacy and safety of cisterna IDDS for pain relief in refractory pain above the middle thoracic vertebrae level in advanced cancer patients. Methods: This study protocol allows for eligible cancer patients to receive the cisterna IDDS operation. Pain intensity (Visual Analogue scale, VAS), quality of life (36-Item Short-Form Health Survey, SF-36), and depression (Self-Rating Depression scale, SDS) are assessed along with side effects in the postoperative follow-up visits. Recent literature suggests a potential role for cisterna IDDS morphine delivery for refractory pain states above the middle thoracic level. Conclusion: The results of this study may provide further evidence that cisterna IDDS of morphine can serve as an effective and safe pain relief strategy for refractory pain above the middle thoracic vertebrae level in advanced cancer patients. | en |
| DOI | https://doi.org/10.5812/aapm.115873 | en |
| Keyword | Cisterna Magna | en |
| Keyword | Refractory Pain | en |
| Keyword | Cancer Patients | en |
| Keyword | Intrathecal Pump | en |
| Keyword | Morphine | en |
| Publisher | Brieflands | en |
| Title | Programmable Pump for Intrathecal Morphine Delivery to Cisterna Magna: Clinical Implications in Novel Management of Refractory Pain Above Middle Thoracic Vertebrae Level Utilizing a Prospective Trial Protocol and Review | en |
| Type | Methods Article | en |
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