Triggers, Bullets and Targets, Puzzle of Membranous Nephropathy
| Author | Mohammadreza Ardalan | en |
| Issued Date | 2012-09-01 | en |
| Abstract | Introduction: Idiopathic Membranous Nephropathy (MN) is a common cause of adult nephrotic syndrome. Recently, M-type phospholipase A2 receptor (PLA2-R) has been discovered as the main podocyte antigen in the pathogenesis of idiopathic MN. Materials and Methods: In this mini review, the author searched English-language MEDLINE for the terms “membranous nephropathy”, “rituximab”, and “phospholipase A2 receptor” up to October 2011. Results: In support of its earlier discovery, reports from China and Europe confirmed the major pathogenic role of non-complement fixing IgG4 antibody against PLA2-R in the pathogenesis of idiopathic MN. Antibodies against aldose reductase (AR) and manganese superoxide dismutase (SOD2 ), and sub-epithelial deposition of cationic bovine serum albumin (BSA) are also reported in rare occasions. It seems that Rituximab is a good therapeutic choice for those patients who need immunosuppressive therapy. Conclusions: Great discoveries in the diagnosis and treatment of idiopathic MN have been performed but pathogenic mechanism and triggers for anti-PLA2-R production are still unknown. | en |
| DOI | https://doi.org/10.5812/numonthly.2330 | en |
| Keyword | Glomerulonephritis | en |
| Keyword | Membranous | en |
| Keyword | Phospholipase A2 | en |
| Keyword | Rituximab | en |
| Keyword | 6B1 IgG4 Monoclonal Antibody | en |
| Publisher | Brieflands | en |
| Title | Triggers, Bullets and Targets, Puzzle of Membranous Nephropathy | en |
| Type | Review Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 16965-pdf.pdf
- Size:
- 848.21 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF