Relationship Between Insulin like Growth Factor-1 and Leptin in Type II Diabetic Patients

Abstract

Background:Diabetes is a common endocrine disease in humans. Leptin secretion is influ-enced by many factors and although the growth hormone/insulin like growth factor (GH/IGF) axis plays an important role in the regulation of body compo-sition, the physiological interaction between Leptin and IGF-1 system remain unknown. The aim of this study was to investigate the correla-tion between Leptin and IGF-1 in type II diabet-ics and controls.Materials and Methods: This case-control study was consisted of 38, type 2 diabetics (20 males and 18 females, mean age 49.33 ± 11.33,years) and 46 healthy controls (16 males and 30 females, mean age 49.52 ± 7.99,years). We measured the concentrations of fasting plasma glucose (FPG), IGF-1, hemoglobin A1C (HbA1c) and insulin like growth factor binding protein-3(IGFBP-3) in both groups. FPG was measured by the enzymat-ic glucose oxidase method and the Hb Gold ana-lyzer HPLC was used to measure HbA1C. For de-termination of leptin, IGF-1, IGFBP-3 and insu-lin concentrations, the enzyme linked immuno-sorbent assay (ELISA) method was used. P< 0.05 was considered statistically significant.Results: Means of BMI and age did not differ significantly between the two groups. Mean se-rum levels of IGF-1, leptin, insulin, FPG and HbA1c concentrations in type 2 diabetics were significantly higher than in controls (p