Effects of chronic administration of norharman on spatial learning and memory in female rats
| Author | Mohammad-Hossein Esmaili | en |
| Author | M Hassani | en |
| Author | M Ashouri | en |
| Author | R Amanea goragi | en |
| Author | F Mosavi | en |
| Issued Date | 2014-09-30 | en |
| Abstract | Background: The exogenous and endogenous β-carbolines , and some of their metabolites have a stimulating effect on the dopaminergic system. β-carbolines can also improve learning and memory while increase hippocampal dopamine levels and dendritic and synaptic proliferation . Objective: The aim of this study was to investigate the effects of chronic administration of norharman on spatial learning and memory in rats. Methods: In this experimental study, 48 f emale wistar rats were randomly divided into control, alchohol and 4 norharmane groups. The control group were received no treatment. In alchohol and norharman groups, rats were received 0.2 ml alchohol or 1, 2, 3 or 4 mg/kg norharman intraperitoneally for 5 days before tests and 5 days during tests. All rates were tested for spatial learning and memory in the Morris water maze. Data were analyzed using student T-test, one way ANOVA and LSD as post hoc test. Findings: N orharman improved spatial learning in a dose dependent manner. T he difference between the 4 mg/kg norharman group and the control group was statistically significant in the 2nd day . N orharman also improved spatial memory in which lower doses improved spatial memory more than higher doses. T he difference between the 2 mg/kg and 4 mg/kg norharman groups was statistically significant. Conclusion: With regards to the results, norharman as an endogenous bioactive molecule, might have a key role in the modulation of learning and memory functions. | en |
| DOI | https://doi.org/ | en |
| Keyword | Norharman | en |
| Keyword | Learning | en |
| Keyword | Memory | en |
| Publisher | Brieflands | en |
| Title | Effects of chronic administration of norharman on spatial learning and memory in female rats | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- article-1-1566-en.pdf.pdf
- Size:
- 261.21 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF