Susceptibility of Protoscoleces of Hydatid Cyst to Various Concentrations of Oak Gall (<i>Quercus infectoria</i> Olivier) Extract at Different Exposure Times <i>In Vitro</i>
| Author | Farnaz Malekifard | en |
| Author | Fatemeh Keramati | en |
| Issued Date | 2018-05-31 | en |
| Abstract | Background: Chemotherapy is currently used in treatment of different diseases, yet its various adverse effects has led to difficulties in its use for treating hydatid cysts. This leads to use of different non-chemical materials, such as plant extracts as alternatives to chemotherapy in order to cure hydatid cysts. Objectives: The aim of the present study was to investigate Quercus infectoria Olivier extract effects on hydatid cysts. Methods: In this experimental study, various concentrations of Quercus infectoria Olivier extract at different exposure times were evaluated under laboratory conditions for their scolicidal effects on hydatid cysts. To this end, protoscoleces were collected from the livers of sheep affected by hydatid cysts and they were placed under exposure of various concentrations of Q. infectoria extract (10, 25, and 50 mg/mL) for various durations of 10, 20, 30, and 60 minutes. Staining with 0.1% eosin was used to specify the viability of protoscoleces. The SPSS software (version 19, Chicago) was the software used to perform the statistical analysis. Results: The obtained results indicate that Q. infectoria extract with the concentration of 50 mg/mL is able to kill all protoscoleces during 20 minutes. It is understood that the scolicidal effects of Q. infectoria on hydatid cysts was significant compared to the control groups (P < 0.05). Conclusions: The obtained results delineate higher scolicidal efficacy of Q. infectoria’s methanolic extracts; nevertheless, more research should be conducted to confirm the in vivo effects of Q. infectoria on curing hydatid cysts in human beings and different herbivorous animals. | en |
| DOI | https://doi.org/10.5812/zjrms.61316 | en |
| Keyword | <i>Quercus infectoria</i> Olivier Extract | en |
| Keyword | Hydatid Cyst | en |
| Keyword | <i>In Vitro</i> | en |
| Keyword | Protoscolex | en |
| Publisher | Brieflands | en |
| Title | Susceptibility of Protoscoleces of Hydatid Cyst to Various Concentrations of Oak Gall (<i>Quercus infectoria</i> Olivier) Extract at Different Exposure Times <i>In Vitro</i> | en |
| Type | Research Article | en |
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