Analysis of CTLA-4 (+49A/G) Gene Polymorphism and the Risk of Tuberculosis in Southeast of Iran
| Author | Edris Paad | en |
| Author | Mohammad Kordi Tamendani | en |
| Author | Mohammad Hosain Sangtarash | en |
| Author | Mansoor Dehvari | en |
| Orcid | Mohammad Kordi Tamendani [0000-0001-7727-3814] | en |
| Issued Date | 2014-10-01 | en |
| Abstract | Background: Tuberculosis (TB) is an acute or chronic bacterial infection caused by Mycobacterium tuberculosis. It primarily affects the lungs, but may spread to other organs (extra-pulmonary TB). Objectives: Studies have shown that genetic predisposition can decrease the persistence and growth of M. tuberculosis. The current study highlights the effect of CTLA-4 (+49A/G) gene polymorphism on the risk of TB. Patients and Methods: This case-controlled study used tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) to analyze theCTLA-4 (+49A/G) gene polymorphism in 100 patients with TB and 91 healthy individuals. Results: Data analysis indicated that the frequencies of AA, AG and GG genotypes were 42%, 38%, and 20% in patients with TB and 43%, 47%, 1% in the control subjects, respectively. The GG genotype of CTLA-4 (+49A/G) showed a significantly increased risk of disease (OR = 20.48; 2.63-159.60) Conclusions: The results revealed a significant relationship between the GG genotype of CTLA-4 and the increased risk of TB. | en |
| DOI | https://doi.org/10.17795/gct-23996 | en |
| Keyword | <i>Tuberculosis</i> | en |
| Keyword | <i>Mycobacterium</i> | en |
| Keyword | <i>CTLA-4</i> | en |
| Publisher | Brieflands | en |
| Title | Analysis of CTLA-4 (+49A/G) Gene Polymorphism and the Risk of Tuberculosis in Southeast of Iran | en |
| Type | Research Article | en |
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