Distribution of EGFR R521K Polymorphism in Different Iranian Ethnic Groups

Abstract

Background: The R521K polymorphism of EGFR has attenuated function in ligand binding, tyrosine kinase activation, and growth stimulation. Objectives: We initiated a study to examine R521K polymorphism in six Iranian ethnic groups. Patients and Methods: This cohort study was designed on 300 Iranian healthy individuals and analyzed by PCR-RFLP protocol. Results: The frequencies of A/A, G/A, G/G genotype were 7.7%, 53.6% and 38.7% respectively. Conclusions: No subject with A/A genotype was detected in Kurds and Lures. The higher frequencies of A/A genotype in Arab and Caspian groups compared to Fars and Turks could be a key determinant of better response to anticancer drugs and favorable prognosis of CRC patients.