Distribution of EGFR R521K Polymorphism in Different Iranian Ethnic Groups
| Author | Asal Shahrokhshahi | en |
| Author | Massoud Houshmand | en |
| Issued Date | 2016-04-27 | en |
| Abstract | Background: The R521K polymorphism of EGFR has attenuated function in ligand binding, tyrosine kinase activation, and growth stimulation. Objectives: We initiated a study to examine R521K polymorphism in six Iranian ethnic groups. Patients and Methods: This cohort study was designed on 300 Iranian healthy individuals and analyzed by PCR-RFLP protocol. Results: The frequencies of A/A, G/A, G/G genotype were 7.7%, 53.6% and 38.7% respectively. Conclusions: No subject with A/A genotype was detected in Kurds and Lures. The higher frequencies of A/A genotype in Arab and Caspian groups compared to Fars and Turks could be a key determinant of better response to anticancer drugs and favorable prognosis of CRC patients. | en |
| DOI | https://doi.org/10.17795/zjrms-6438 | en |
| Keyword | Colorectal Cancer | en |
| Keyword | Epidermal Growth Factor Receptor | en |
| Keyword | R521K Polymorphism | en |
| Keyword | Iranian Ethnic Groups | en |
| Publisher | Brieflands | en |
| Title | Distribution of EGFR R521K Polymorphism in Different Iranian Ethnic Groups | en |
| Type | Brief Report | en |
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