The Role of Ketamine in Calcium Changes in Intracellular Homeostasis and Mitochondrial Dysfunction
| Author | Legiran Legiran | en |
| Author | Irfannuddin Irfannuddin | en |
| Author | Ramli Ahmad | en |
| Author | Nurhadi Ibrahim | en |
| Author | Rizal Zainal | en |
| Orcid | Legiran Legiran [0000-0002-9770-2978] | en |
| Orcid | Irfannuddin Irfannuddin [0000-0002-2217-367X] | en |
| Orcid | Ramli Ahmad [0000-0003-0080-6103] | en |
| Orcid | Nurhadi Ibrahim [0000-0003-3682-0820] | en |
| Orcid | Rizal Zainal [0000-0001-7107-5198] | en |
| Issued Date | 2024-06-30 | en |
| Abstract | Ketamine was formerly introduced as an anesthesia drug and known as a non-competitive antagonist of the N-methyl-D-aspartate receptor (NMDAR). As knowledge grows, recent studies reveal the antidepressant effect of the drug. Moreover, a few investigations indicate that ketamine might be responsible for multiple calcium-regulated signaling pathways. Ketamine is thought to affect calcium homeostasis through several of its targets, such as N-Methyl-D-Aspartate (NMDA), α-amino-3-hydroxy-5-methylisoxazole-4-propionate acid receptors (AMPA), and voltage-dependent calcium channels (VDCCs). | en |
| DOI | https://doi.org/10.5812/jcma-146644 | en |
| Keyword | Cellular | en |
| Keyword | Ketamine | en |
| Keyword | N-Methyl-D-Aspartate (NMDA) | en |
| Keyword | Pain | en |
| Publisher | Brieflands | en |
| Title | The Role of Ketamine in Calcium Changes in Intracellular Homeostasis and Mitochondrial Dysfunction | en |
| Type | Review Article | en |