Molecular Basis of Inherited Factor XIII- A Deficiency among Patients from Sistan - Baluchestan
| Author | gholamhossein tamaddon | en |
| Author | Ahmad Kazemi | en |
| Author | Ghasem Rastgarlari | en |
| Author | Fereidoon Ala | en |
| Author | Shabnam Hejazi | en |
| Issued Date | 2010-01-31 | en |
| Abstract | Background : Factor ХШ, the last zymogene in the clotting cascade, converts the loose fibrin polymer into a firm polymer. In the absence of factor ХШ the abnormal fibrin is soluble in acetic acid, as well as 5M urea. Factor ХШ is composed of 2 catalytic A subunit bounds and 2 B subunits as carriers (A2B2). The gene of A chain is located on chromosome 6. Factor ХШ deficiency is rare with a prevalence of only 1 in 2 million in the general population. The overwhelming majority of cases are due to mutations in subunit A. The aim of this study was to detect the mutations of subunit A. | en |
| DOI | https://doi.org/ | en |
| Keyword | Factor ХШ | en |
| Keyword | Factor XIII-A deficiency | en |
| Keyword | Coagulation system | en |
| Keyword | Zahedan | en |
| Publisher | Brieflands | en |
| Title | Molecular Basis of Inherited Factor XIII- A Deficiency among Patients from Sistan - Baluchestan | en |
| Type | Research Article | en |
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