Effect of subcutaneous injection of morphine on activity of neurons in the nucleus cuneiformis of rat
| Author | Abbas Haghparast |
| Author | AmirMohammad Alizadeh |
| Author | Fereshteh Motamedi |
| Accessioned Date | 2023-12-23T15:34:35Z |
| Available Date | 2023-12-23T15:34:35Z |
| Issued Date | 2008-12-31 |
| Abstract | Background: The similarities between periaqueductal gray matter and the nucleus cuneiformis in both ultrastructural and functional levels suggest that this nucleus may play an important role in the morphine-induced analgesia. This study was designed to determine neuronal activity and responsiveness to peripheral morphine administration in the nucleus coneiformis of rat. Materials and Methods: In this study, neural activity of cuneiform neurons in response to peripheral administration of morphine was recorded by extracellular single unit recording technique. Firing rate of neurons was recorded in four groups: intact group (n=19) to determine the spontaneous (baseline) activity, saline group (n=20), morphine group (n=39) and morphine + naloxone group (n=12), before and after drug administration. Results: Our findings showed that the firing rate in majority of cuneiform neurons decreased after morphine (3.8 mg/kg; SC) administration. Activity of neurons (n=39) in the cuneiform neurons was reduced significantly (P |
| DOI | https://doi.org/ |
| URI | https://repository.brieflands.com/handle/123456789/29720 |
| Keyword | Nucleus cuneiformis |
| Keyword | Morphine |
| Keyword | Neural activity |
| Keyword | Single unit recording |
| Keyword | Pain |
| Keyword | Rat |
| Publisher | Brieflands |
| Title | Effect of subcutaneous injection of morphine on activity of neurons in the nucleus cuneiformis of rat |
| Type | Research Article |