Splenic Marginal Zone Lymphoma and Concurrent Membranoproliferative Glomerulonephritis With IgMKappa Deposits in a HCV-Seropositive Patient
| Author | Eleni Chelioti | en |
| Author | Evdokia Efthimiou | en |
| Author | Maria Sotiraki | en |
| Author | Alexia Papalexandrou | en |
| Author | Maria Tsilivigkou | en |
| Issued Date | 2014-07-01 | en |
| Abstract | We report a case of membranoproliferative glomerulonephritis (MPGN) with IgMκ light chain deposits in a patient with chronic hepatitis C infection and simultaneous onset of monoclonal IgMκ gammopathy with concurrent small B-cell lymphoproliferative disease. The patient presented with hepatosplenomegaly and a uremic state that necessitated dialysis without any clinical signs of systemic disease apart from the chronic infection with hepatitis C virus. The diagnostic approach led to a renal biopsy that revealed MPGN with dominant IgMκ deposits and interstitium infiltration by the lymphoid cells. The bone marrow biopsy findings were consistent with splenic marginal zone lymphoma, a rare lymphoproliferative disorder with a rare association with MPGN. Our case indicates high diagnostic value of renal biopsy for rare lymphoplasmacytic neoplasms with renal dysfunction as their predominant clinical manifestation. | en |
| DOI | https://doi.org/10.5812/numonthly.18391 | en |
| Keyword | Hepatitis C | en |
| Keyword | Membranoproliferative Glomerulonephritis | en |
| Keyword | Lymphoma | en |
| Keyword | B-Cell | en |
| Keyword | Marginal Zone | en |
| Keyword | Kidney | en |
| Keyword | Biopsy | en |
| Publisher | Brieflands | en |
| Title | Splenic Marginal Zone Lymphoma and Concurrent Membranoproliferative Glomerulonephritis With IgMKappa Deposits in a HCV-Seropositive Patient | en |
| Type | Case Report | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 17128-pdf.pdf
- Size:
- 474.54 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF