Effects of General Anesthesia Versus Spinal Anesthesia on Serum Cytokine Release After Cesarean Section: A Randomized Clinical Trial
| Author | Maryam Vosoughian | en |
| Author | Mastaneh Dahi | en |
| Author | Shideh Dabir | en |
| Author | Mohammadreza Moshari | en |
| Author | Soodeh Tabashi | en |
| Author | Zahra Mosavi | en |
| Orcid | Maryam Vosoughian [0000-0001-9377-3587] | en |
| Orcid | Mastaneh Dahi [0000-0001-5732-475X] | en |
| Orcid | Shideh Dabir [0000-0003-2242-7382] | en |
| Orcid | Mohammadreza Moshari [0000-0002-9945-9019] | en |
| Orcid | Soodeh Tabashi [0000-0003-3430-5075] | en |
| Issued Date | 2021-04-30 | en |
| Abstract | Background: Tissue damage caused by major surgery, such as cesarean section, may lead to a poor host immune response and excessive release of cytokines. These responses may increase the risk of infection, cause postoperative pain, and exert damaging effects on various body organs. Objectives: Anesthesia methods may affect cytokine production after surgery. This study aimed to compare the serum levels of cytokines in general and spinal anesthesia among women undergoing cesarean section. Methods: Thirty parturients (ASA class I and II) undergoing cesarean section were randomly assigned into two equal groups of spinal anesthesia and general anesthesia. Blood samples were taken for measuring the levels of interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-α) before induction of anesthesia and 30 minutes after entering the recovery room. Results: In the general anesthesia group, the postoperative serum levels of IL-6 and TNF-α were significantly higher than the corresponding preoperative levels. Significant differences were found between the two groups in the preoperative and postoperative levels of TNF-α. Changes in the IL-6 and TNF-α concentrations were significantly higher in the general anesthesia group as compared to the spinal anesthesia group. However, there was no significant difference in the IL-6:IL-10 and TNF-α: IL-10 ratios between the two groups. Conclusions: General anesthesia, as compared to spinal anesthesia, significantly increased the IL-6 and TNF-α levels after cesarean section. Therefore, the spinal anesthesia technique may be a better option for patients undergoing cesarean section. | en |
| DOI | https://doi.org/10.5812/aapm.111272 | en |
| Keyword | Cesarean Section | en |
| Keyword | General Anesthesia | en |
| Keyword | Spinal Anesthesia | en |
| Keyword | Cytokines | en |
| Publisher | Brieflands | en |
| Title | Effects of General Anesthesia Versus Spinal Anesthesia on Serum Cytokine Release After Cesarean Section: A Randomized Clinical Trial | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- aapm-11-2-111272.pdf
- Size:
- 150.85 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF