The Effects of Intravenous Vitamin C on Stress Response Severity in Abdominal Hysterectomy Following Prolonged Fasting Time
| Author | Vali Imantalab | en |
| Author | Mandana Mansour Ghanaie | en |
| Author | Zahra Rafiei Sorouri | en |
| Author | Ali Mohammadzadeh Jouryabi | en |
| Author | Samaneh Ghazanfar Tehran | en |
| Author | Haniyeh Sadat Fayazi | en |
| Author | Gelareh Biazar | en |
| Author | Mehdi Noroozshamsi | en |
| Orcid | Vali Imantalab [0000-0001-6444-0329] | en |
| Orcid | Mandana Mansour Ghanaie [0000-0001-6165-7071] | en |
| Orcid | Zahra Rafiei Sorouri [0000-0003-2286-6983] | en |
| Orcid | Ali Mohammadzadeh Jouryabi [0000-0001-5228-8761] | en |
| Orcid | Samaneh Ghazanfar Tehran [0000-0002-9910-2394] | en |
| Orcid | Haniyeh Sadat Fayazi [0000-0002-5686-2836] | en |
| Orcid | Gelareh Biazar [0000-0002-4571-6059] | en |
| Issued Date | 2021-10-31 | en |
| Abstract | Background: Inevitable prolonged fasting time before surgery leads to inflammatory reactions, surgery-related stress response, and consequently unfavorable outcomes; thus, developing strategies to mitigate these consequences is crucial. Objectives: In this study, we evaluated the effect of ascorbic acid on stress response reduction in abdominal hysterectomy following prolonged fasting time. Methods: Eligible women candidates for abdominal hysterectomy following prolonged fasting time were enrolled in the study and divided into 2 groups of vitamin C [group C; 1 g intravenously (IV) before surgery] and placebo (group P). Before induction of anesthesia, C-reactive protein (CRP), mean arterial pressure (MAP), heart rate (HR), and blood sugar (BS) were measured and compared between the 2 groups at 4-point times, 24 and 48 hours immediately after extubation. Results: Finally, the data of 80 patients were included for the final analysis. A statistically significant difference was observed between the 2 groups in terms of CRP and BS values in T1 CRP serum levels; at the end of the study, CRP values were 0.5 ± 0.55 and 0.92 ± 0.69 in groups C and P, respectively (P = 0.012), and BS levels were 124.12 ± 18.11 and 152.0 ± 17.36 in groups C and P, respectively (P = 0.0001). However, this significant difference was not observed at T2 regarding CRP (P = 0.145) and BS (P = 0.135), as well as at T3 regarding CRP (P = 0.282) and BS (P = 0.213). However, according to both CRP and BS values, the trend of changes from T0 to T3 was significant in the 2 groups (P < 0.0001). Hemodynamic parameters were not significantly different between the 2 groups. No adverse event was reported in the 2 groups. Conclusions: We found that ascorbic acid could induce short-term positive effects in abdominal hysterectomy following prolonged fasting time. Obviously, the optimal dosage, timing, and specific cases that benefit the most from this intervention should be investigated. | en |
| DOI | https://doi.org/10.5812/aapm.119332 | en |
| URI | https://brieflands.com/journals/aapm/articles/119332 | en |
| Keyword | Hysterectomy | en |
| Keyword | Fasting | en |
| Keyword | Metabolic Stress Responses | en |
| Keyword | Vitamin C | en |
| Publisher | Brieflands | en |
| Title | The Effects of Intravenous Vitamin C on Stress Response Severity in Abdominal Hysterectomy Following Prolonged Fasting Time | en |
| Type | Research Article | en |
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