Orexin (hypocretin): A multi-functional hypothalamic peptide
| Author | Mohammad Shabani | en |
| Author | Mohammad Mohammad-Zadeh | en |
| Author | hassan Azhdari Zarmehri | en |
| Issued Date | 2014-06-30 | en |
| Abstract | Hypocretins/orexins are novel hypothalamic neuropeptides involved in various hypothalamic mechanisms, such as energy homeostasis and neuroendocrine function. Orexins A (33 amino acids) and B (28 amino acids) are derived from a single pre-pro-orexin polypeptide. Physiological studies over the last ten years have implicated orexin signaling plays a central role in a variety of important biological processes. There is a clear evidence for defects in orexin signaling being involved in obesity and diabetes, narcolepsy, panic anxiety disorder and drug addiction. Therefore, this system may be a potentially important therapeutic target for treatment of sleep disorder, obesity, emotional stress, and addiction. In addtion, it has been well known that orexin-A elicits analgesia. Thus, there is a considerable interest in the drug industry in the development of potent compounds for the manipulation of orexin signaling. Therefore, This a review about recent progress in understanding orexin system | en |
| DOI | https://doi.org/ | en |
| Keyword | Orexin (hypocretin), Hypothalamic peptide, Reward system, Obesity, Sleep disorder, Addiction | en |
| Keyword | اورکسین(هیپوکرتین)، پپتید هیپوتالاموسی، سیستم پاداش، چاقی، خواب آلودگی، اعتیاد | en |
| Publisher | Brieflands | en |
| Title | Orexin (hypocretin): A multi-functional hypothalamic peptide | en |
| Type | Research Article | en |
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