Absence of Immune Response as a Sign of Tissue Tolerance in Small-Cell Lung Cancer
| Author | Antonio Manenti | en |
| Author | Luca Roncati | en |
| Author | Pamela Sighinolfi | en |
| Author | Giuseppe Barbolini | en |
| Issued Date | 2014-07-01 | en |
| Abstract | Background: The attention of the scientific community has been recently focused on the role of tumor-infiltrating lymphocytes in non-small-cell cancer and there is a convergence of results, supporting a direct proportionality between lymphocytic infiltrate and good prognosis. Objectives: The aim of our research was to investigate the immune response around and inside the small-cell lung neoplastic tissue and its related neo-lymphangiogenesis in a group of 20 patients. Materials and Methods: We have examined 20 bioptic samples of small cell lung cancer, obtained from 18 men and two women, aged 56-74 years old. Besides hematoxylin-eosin staining, immunohistochemistry for neuroendocrine markers (CD56, chromogranin) and D2-40 was performed following the standard protocols. Results: Our histological analysis, in all cases, has emerged the absence of an immune response supported by an adequate neo-lymphangiogenesis inside the neoplasia. Conclusions: The absence of an immune response is interpreted as a sign of tissue tolerance and host acceptance towards the cancer, in favor of the cancer metastatic spread. The development of a paraneoplastic syndrome can be considered a biochemical proof of this tissue compatibility. | en |
| DOI | https://doi.org/10.17795/gct-20330 | en |
| Keyword | Small Cell Lung Carcinoma | en |
| Keyword | Antigens | en |
| Keyword | CD56 | en |
| Keyword | Chromogranins | en |
| Keyword | Monoclonal Antibody D2-40 | en |
| Keyword | Paraneoplastic Syndrome | en |
| Publisher | Brieflands | en |
| Title | Absence of Immune Response as a Sign of Tissue Tolerance in Small-Cell Lung Cancer | en |
| Type | Brief Report | en |
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