Evaluating the Compatibility of Treatment Protocol for Intravesical Non-muscle Invasive Bladder Cancer with the National Clinical Guideline at Urmia Imam Khomeini Hospital
| Author | Mohammad Sadri | en |
| Author | Sima Masudi | en |
| Author | Milad Sheykhian | en |
| Author | Ali Tayyebi-Azar | en |
| Issued Date | 2025-02-28 | en |
| Abstract | Background: Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease characterized by a high risk of recurrence and progression. Clinicians have various surgical and therapeutic options available for managing NMIBC. Objectives: This evaluated the alignment of treatment practices at all hospitals in Urmia, a south-west province of Iran, with current guidelines for treating NMIBC. Methods: This cross-sectional study included 134 patients with NMIBC. Demographic data, medical history, perioperative intravesical therapy, imaging results, cytology findings, and surgical procedures were collected. Intravesical chemotherapy with mitomycin C, and post-surgical immunotherapy with Bacillus calmette-guérin (BCG) including induction and maintenance regimens and durations, were also recorded. Treatment protocols were compared to established guidelines using IBM SPSS statistics version 21. Results: The mean age of patients was 65 years, with 79.17% being male. Adherence to clinical guidelines was 45.5% for obtaining a separate sample from the tumor base, 40.3% for urinary cytology, 67.9% for performing re-transurethral resection of bladder tumors (TURBT), and 68.4% for performing re-TURBT within the appropriate timeframe. Among the patients indicated for re-TURBT, only 30% underwent the procedure. Mitomycin treatment was not used in 94.4% of low-risk patients. Induction treatment with BCG was compatible with guidelines in 86.6% of patients. Compliance with maintenance treatment was 69.8%, and adherence to the recommended duration was 55.2%. Only 55% of patients with indications received maintenance treatment. Overall treatment compliance with clinical guidelines was good in 19.4%, intermediate in 32.8%, and poor in 47.8%. Conclusions: Overall adherence to clinical guidelines for the management of NMIBC was found to be suboptimal, particularly among low-risk patients. | en |
| DOI | https://doi.org/10.5812/numonthly-157917 | en |
| URI | https://brieflands.com/journals/num/articles/157917 | en |
| Keyword | Bladder Cancer | en |
| Keyword | Non-muscle Invasive | en |
| Keyword | Practice Guidelines | en |
| Keyword | Transurethral Resection of Bladder Tumor (TURB) | en |
| Publisher | Brieflands | en |
| Title | Evaluating the Compatibility of Treatment Protocol for Intravesical Non-muscle Invasive Bladder Cancer with the National Clinical Guideline at Urmia Imam Khomeini Hospital | en |
| Type | Research Article | en |
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