Reduction of Complements C<sub>3</sub> and C<sub>4</sub> in Saliva and Serum of Patients Suffering SARS-CoV-2 Infection
| Author | Nima Rahimi Petrudi | en |
| Author | Iraj Mirzaii-Dizgah | en |
| Author | Ali Atashabparvar | en |
| Author | Seyyed-Javad Hosseini-Shokouh | en |
| Orcid | Nima Rahimi Petrudi [0000-0002-1866-0600] | en |
| Orcid | Iraj Mirzaii-Dizgah [0000-0002-0050-4191] | en |
| Orcid | Ali Atashabparvar [0000-0001-7130-7817] | en |
| Issued Date | 2023-12-31 | en |
| Abstract | Background: The complement system plays a role in chronic immune activation during viral infections. Objectives: This study aimed to evaluate the levels of saliva and serum complements C3 and C4 in coronavirus disease 2019 (COVID-19) patients and healthy individuals. Methods: This cross-sectional study included 36 severe and 22 critical COVID-19 hospitalized patients and 22 healthy individuals. Serum and unstimulated salivary C3 and C4 levels were assessed using the immunoturbidimetric method and analyzed using one-way analysis of variance (ANOVA) with the Student-Newman-Keuls test as a post hoc analysis. Results: Salivary C3 and C4 levels were significantly lower in patients with severe and critical COVID-19 than in healthy individuals. There was no significant difference between the groups infected with severe and critical COVID-19. Serum C3 and C4 levels were lower in critical COVID-19 patients than in healthy individuals; nevertheless, no significant difference was observed between severe COVID-19 patients and healthy individuals. Additionally, serum C4 levels were lower in critical COVID-19 patients than in severe COVID-19 patients. Conclusions: It appears that serum and salivary C3 and C4 levels decrease in patients with COVID-19 infection. | en |
| DOI | https://doi.org/10.5812/amh-143102 | en |
| Keyword | Complement Proteins | en |
| Keyword | Saliva | en |
| Keyword | Serum | en |
| Keyword | COVID-19 | en |
| Publisher | Brieflands | en |
| Title | Reduction of Complements C<sub>3</sub> and C<sub>4</sub> in Saliva and Serum of Patients Suffering SARS-CoV-2 Infection | en |
| Type | Research Article | en |
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