Effect of cimetedine on multiple warts

Abstract

Wart is a viral disease; it has many different types and has many different methods of treatment. Oral cimetedine is a safe method for recalcitrant multiple common warts, although it has been reported as a successful method, it hasn’t been used as a routine method yet. This study was performed to determine the effect of cimetedine on recalcitrant multiple warts. It was a single - blind clinical trial study in 1379-1380 in Khatam - Al - Anbia hospital in Zahedan. 42 patients in two groups were included; after unifying them considering location, number and type of warts: the patients were randomly divided in two groups; the first group were treatment with cimetedine 30 mg \kg daily for 3 months and the second group were treated with placebo for 3 months. After 3 month patients were evaluated. Inclusion criteria: recalcitrant multiple warts, not using cimetedine and other immunodeficient drugs, not having any contraindication for cimetedine and no history of lymphoma and leukemia. Results were interpreted using chi - square test. In cease group 8 patients (%19) showed an absolute improvment, 7 patients (%17) a relative improvement and 27 patients (%64) had no improvement. In control group 5 patients (%12) had an absolute improvment, 3 patients (%7) a relative improvement, and 34 patients (%81) had no improvment. In both groups no significant difference between drug and improvement was abserved (P>0/05). But when we divided the patients into two age sub groups in both main groups, 12 and under 12and over 12 years old, no differences in the two subgroup of case group Between treatment and age patient was seen, but in control group in 12 and lower 12 years old a significant diffrence between placebo treatment and age was observed (P =0/01307). This study showed that cimetedine is not more effective than placebo so it is similar to other reserches; However, this study showed treatment with placebo in children with multiple warts must be highly considered like in some other skin diseases such as chronic urticaria, alopcia areata, and lichen planus which are treated by plaecbo.