Prevalence of Cytomegalovirus Infection in Patients With Ulcerative Colitis by Using PCR Technique
| Author | Sahar Mehrabani-Khasraghi | en |
| Author | Mitra Ameli | en |
| Author | Farzad Khalily | en |
| Author | Masood Ghane | en |
| Issued Date | 2015-11-28 | en |
| Abstract | Background:: Ulcerative colitis is one type of inflammatory bowel disease. Objectives:: The aim of this study was to investigate the prevalence of cytomegalovirus in patients with ulcerative colitis in comparison with healthy subjects by using PCR technique. Patients and Methods:: In this analytical case-control study, 5 patients with ulcerative colitis and 30 patients without malignancy as controls were selected. Biopsy specimens were frozen under sterile conditions at -20ºC. After DNA extraction, analysis of polymerase chain reaction (PCR) to detect CMV DNA in tissue samples was performed. Statistical analysis was performed with χ2 test. Results:: CMV DNA was found in 80% of ulcerative colitis samples (4 of 5) and 30% of the non-malignant control group (9 of 30). Statistical analysis showed significant association between the prevalence of CMV and incidence ulcerative colitis in comparison with the control group (P = 0.03). Conclusions:: The results of the present study has shown ulcerative colitis patients have a predisposition to CMV infection as compared to healthy individuals, but the etiologic link between ulcerative colitis and CMV infection needs to be studied. | en |
| DOI | https://doi.org/10.17795/zjrms-2218 | en |
| Keyword | Ulcerative colitis | en |
| Keyword | Cytomegalovirus | en |
| Keyword | Polymerase chain reaction | en |
| Publisher | Brieflands | en |
| Title | Prevalence of Cytomegalovirus Infection in Patients With Ulcerative Colitis by Using PCR Technique | en |
| Type | Research Article | en |
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