Neuroprotective Effects of Fe<sub>3</sub>O<sub>4</sub> Nanoparticles Coated with Omega-3 as a Novel Drug for Recovery of Sciatic Nerve Injury in Rats
| Author | Mehdi Tamjid | en |
| Author | Arash Abdolmaleki | en |
| Author | Fariba Mahmoudi | en |
| Author | Sharareh Mirzaee | en |
| Orcid | Arash Abdolmaleki [0000-0002-7454-8728] | en |
| Issued Date | 2023-04-30 | en |
| Abstract | Background: Novel nanoparticle drug therapy could be an effective method to enhance peripheral nerve regeneration. Objectives: The current study aimed to determine the effect of Fe3O4 nanoparticles (NP) coated with omega-3 on sciatic nerve regeneration in Wistar rats. Methods: The rats' left sciatic nerve was crushed with a non-serrated clamp. Animals in experimental groups were given Fe3O4@ω3 NPs (10 or 30 mg/kg/d) for one week. The recovery of functions was then assessed over eight weeks using a walking track analysis and a hot plate test. In addition, histomorphometry was used to assess the histomorphometric factors. Results: Results showed that Fe3O4@ω3 NPs may have enhanced sciatic nerve regeneration and improved sensorimotor rehabilitation in comparison to the negative controls. These therapeutic effects were significantly greater in Fe3O4@ω3 NPs at a dose of 30 mg/kg. Furthermore, Fe3O4@ω3 NPs treatment, compared to negative controls, significantly reduced gastrocnemius muscle atrophy and improved histomorphometric parameters. Conclusions: It was determined that Fe3O4@ω3 NPs had great potential for nerve regeneration due to the ease of their manufacturing and their desired efficacy. | en |
| DOI | https://doi.org/10.5812/gct-124110 | en |
| Keyword | Nanoparticles | en |
| Keyword | Fe<sub>3</sub>O<sub>4</sub> | en |
| Keyword | Sciatic Nerve | en |
| Keyword | Crush | en |
| Keyword | Rat | en |
| Publisher | Brieflands | en |
| Title | Neuroprotective Effects of Fe<sub>3</sub>O<sub>4</sub> Nanoparticles Coated with Omega-3 as a Novel Drug for Recovery of Sciatic Nerve Injury in Rats | en |
| Type | Research Article | en |