Coagulation Factor XIII-A A614T gene Variation is Suggestive of Founder Effect in Iranian Patients with Severe Congenital Factor XIII Deficiency
| Author | Majid Naderi | en |
| Author | Shadi Tabibian | en |
| Author | Shaban Alizade | en |
| Author | Zahra Sadat Abtahi | en |
| Author | Akbar Dorgalaleh | en |
| Issued Date | 2016-03-31 | en |
| Abstract | Background: Factor XIII (FXIII) is a heterotetramer consisting of two subunits, FXIII-A and FXIII-B. Several common gene variations were observed in the FXIII-A gene with an obvious ethnic difference. This study assessed the prevalence of A614T as a common FXIII-A gene variation among Iranian patients with FXIII deficiency (FXIIID). Materials and Methods: This study was conducted on eighty Iranian unrelated individuals with FXIIID. Genotype analysis for FXIII-A A614T gene variation was performed for all individuals. Results: Molecular analysis of these Iranian populations revealed that all studied patients were homozygous for the T allele at codon 204 of the FXIII-A1 subunit. Conclusion: Present of T allele at codon 204 of FXIII-A1 subunit among all study population can be suggestive of founder effect. ? | en |
| DOI | https://doi.org/10.22037/jcma.v1i1.10638 | en |
| Keyword | Coagulation Factor | en |
| Keyword | XIII-A A614T gene | en |
| Keyword | Congenital | en |
| Keyword | Factor XIII Deficiency | en |
| Keyword | Factor XIII | en |
| Keyword | Polymorphism | en |
| Keyword | Mutation | en |
| Publisher | Brieflands | en |
| Title | Coagulation Factor XIII-A A614T gene Variation is Suggestive of Founder Effect in Iranian Patients with Severe Congenital Factor XIII Deficiency | en |
| Type | Original Articles | en |
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