Investigation of Clinical Potential Roles of <i>JS-2</i> Gene in Pathogenesis of Colorectal Cancer

Abstract

Background: Colorectal cancer (CRC) is the third prevalent adenocarcinoma type with a high mortality rate worldwide. The JS-2 is a novel gene, which first was described in esophageal squamous cell carcinoma (ESCC). To date, several studies have investigated the role of JS-2 in the pathogenesis of CRC. Objectives: The purpose of our survey was to assess the JS-2 gene expression level in subjects with CRC in the Iranian population. Methods: The current case-control study was conducted on one hundred fresh tissues, consisting of 50 cancerous colorectal adenocarcinomas and 50 adjacent non-cancerous tissues. The relative JS-2 gene expression level was assessed using quantitative real-time polymerase chain reaction (qReal-Time PCR) method. Results: Our findings showed that the JS-2 gene was significantly over-expressed in cancerous tissues compared with the adjacent non-cancerous tissues (P = 0.037). In addition, overexpression of JS-2 was significantly related to the tumor differentiation (P = 0.047) and tumor stage (P = 0.036). Conclusions: The results suggested that the JS-2 gene played an important role in the progression of CRC and may be applied as a novel prognostic biomarker in patients with CRC.