Sympatholytic and Anti-Inflammatory Effects of Ropivacaine and Bupivacaine After Infraclavicular Block in Arterio Venous Fistula Surgery
| Author | Faranak Behnaz | en |
| Author | Pardis Soltanpoor | en |
| Author | Houman Teymourian | en |
| Author | Niki Tadayon | en |
| Author | Gholam Reza Mohseni | en |
| Author | Mahshid Ghasemi | en |
| Orcid | Faranak Behnaz [0000-0003-2856-3975] | en |
| Orcid | Houman Teymourian [0000-0002-0102-4106] | en |
| Orcid | Gholam Reza Mohseni [0000-0003-1052-1291] | en |
| Orcid | Mahshid Ghasemi [0000-0002-7327-5561] | en |
| Issued Date | 2019-02-28 | en |
| Abstract | Background: Various mechanisms have been suggested for analgesic effects of drugs used in infra-clavicular block and each has contributed to pain relief. Objectives: The aim of this study was to compare the degree of sympathetic block and measure tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1 levels before and after infra-clavicular block with ropivacaine and bupivacaine in patients undergoing arterio venous fistula (AVF) surgery. Methods: Forty-eight patients undergoing AVF surgery were randomly divided to two groups, undergoing infra-clavicular block with ropivacaine and bupivacaine. The bupivacaine group was blocked with 30 mL of 0.5% bupivacaine and in the ropivacaine group, the blockage was done with 30 mL of 0.5% ropivacaine. Infra-clavicular block was carried out by ultrasound in a vertical manner. Blood samples were taken before the block and one hour after the block to measure IL-1, IL-6, and TNF-alpha. Data were analyzed by covariance analysis and correlation t-test. Results: T-correlation analysis showed that in both ropivacaine and bupivacaine groups, the TNF-alpha, IL-6, and IL-1 levels decreased after the block. Also, the increase in arterial diameter was significantly greater in ropivacaine group. Conclusions: The present study showed that peripheral block with any single drug could reduce pre-inflammatory factors. On the other hand, ropivacaine significantly increased the diameter of the artery compared to the bupivacaine group. | en |
| DOI | https://doi.org/10.5812/aapm.85704 | en |
| Keyword | Infraclavicular Block | en |
| Keyword | Anti-Inflammatory Effect | en |
| Keyword | Sympatholytic | en |
| Keyword | AVF Surgery | en |
| Publisher | Brieflands | en |
| Title | Sympatholytic and Anti-Inflammatory Effects of Ropivacaine and Bupivacaine After Infraclavicular Block in Arterio Venous Fistula Surgery | en |
| Type | Research Article | en |
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