The Effect of Iron Oxide Nanoparticles on Sperm Numbers and Mobility in Male Mice
| Author | Sima Nasri | en |
| Author | Saeid Rezai-Zarchi | en |
| Author | Parisa Kerishchi | en |
| Author | Safora Sadeghi | en |
| Issued Date | 2015-10-28 | en |
| Abstract | Background:: Now a day, Fe2o3 nanoparticles due to high magnetic property and small size are used in MRI imaging. Objectives:: This study aimed to characterize the effect of iron oxide nanoparticles on sperm parameters. Materials and Methods:: This experiment study was carried out on 75 mature male mice that divided into 4 test groups that received iron oxide nanoparticles at the dose levels of 5, 10, 20, 40 mg/kg intraperitaneally (i.p.) for 2 weeks and a control group. Sperm was collected from epididymis and prepared for analysis. Results:: Fe2o3 nanoparticles cause a meaningful reduction in sperm numbers and mobility in all experimental groups. Conclusions:: Nanoparticles can cause the inflammation of epididymis and increasing of free radicals (Reactive oxygen species: ROS) that can decrease the mobility of the sperms. | en |
| DOI | https://doi.org/10.17795/zjrms-2185 | en |
| Keyword | Nanoparticles | en |
| Keyword | Sperm | en |
| Keyword | Male | en |
| Keyword | Mice | en |
| Publisher | Brieflands | en |
| Title | The Effect of Iron Oxide Nanoparticles on Sperm Numbers and Mobility in Male Mice | en |
| Type | Brief Report | en |
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