Clinical and Biochemical Characteristics and Treatment Outcomes of Ketosis-Prone Diabetes: The Remission Prone Diabetes
| Author | Swaraj Shrikant Waddankeri | en |
| Author | Meenakshi Swaraj Waddankeri | en |
| Author | Basavraj Gurushantappa Mangshetty | en |
| Orcid | Swaraj Shrikant Waddankeri [0000-0003-4228-7372] | en |
| Orcid | Meenakshi Swaraj Waddankeri [0000-0003-0561-9462] | en |
| Issued Date | 2021-04-30 | en |
| Abstract | Background: Diabetic ketoacidosis (DKA) is one of the severe acute complications of diabetes. It has long been considered a key clinical characteristic of type 1 diabetes mellitus (T1DM) with severe and irreversible deficient insulin levels. Ketosis-prone diabetes (KPD) has pathophysiology close to T2DM but shows signs and symptoms associated with T1DM. In general, patients with ketosis-prone diabetes display elevated glucose and ketone levels; also, a higher hemoglobin A1C than conventional T2DM. Objectives: The current research aimed to elucidate the clinical presentation and outline a management plan for KPD in the Indian population. Methods: The present case series is a descriptive, prospective, and observational case series on six unprovoked cases of KPD. They were managed using the standard protocol of DKA management. Results: The recruited cases followed a set pattern of very high insulin requirement at diagnosis. On follow-up, the insulin requirement progressively declined, and all of the cases were able to stop insulin therapy after a mean period of four weeks. None of the cases presented any organ damage at diagnosis. There was no recurrence of DKA during the two-year follow-up. All of the cases had normal liver and renal functions. Autoantibodies were negative in all of the cases. Conclusions: Ketosis-prone diabetes is the most under-recognized and under-diagnosed among all types of diabetes. Its recognition is of utmost importance as the approach of its treatment varies widely from that of the conventional type of diabetes. Proper follow-up, especially in unprovoked cases of DKA with obese phenotype, could help elucidate this rare entity of KPD where insulin can be stopped and maintain normoglycemia for a substantial period without insulin. | en |
| DOI | https://doi.org/10.5812/ijem.106799 | en |
| Keyword | Diabetic Ketoacidosis | en |
| Keyword | Remission Prone Diabetes | en |
| Keyword | Ketosis-Prone Diabetes | en |
| Publisher | Brieflands | en |
| Title | Clinical and Biochemical Characteristics and Treatment Outcomes of Ketosis-Prone Diabetes: The Remission Prone Diabetes | en |
| Type | Research Article | en |
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