Comparison of Three Different Doses of Dexmedetomidine Added to Bupivacaine in Ultrasound-Guided Transversus Abdominis Plane Block; A Randomized Clinical Trial
| Author | Gilda Talebi | en |
| Author | Hassan Moayeri | en |
| Author | Khaled Rahmani | en |
| Author | Karim Nasseri | en |
| Orcid | Gilda Talebi [0000-0001-8197-7777] | en |
| Orcid | Hassan Moayeri [0000-0003-3221-476X] | en |
| Orcid | Khaled Rahmani [0000-0002-0860-8040] | en |
| Orcid | Karim Nasseri [0000-0002-0033-3820] | en |
| Issued Date | 2021-04-30 | en |
| Abstract | Background: Adding dexmedetomidine to bupivacaine has been shown to prolong the analgesic effects of the transversus abdominis plane (TAP) block. However, the optimal dose of this adjuvant drug is unclear. Objectives: Identifying optimal doses of dexmedetomidine added to bupivacaine in the TAP block. Methods: In this randomized controlled trial, 86 patients candidate for elective open inguinal herniorrhaphy under spinal anesthesia were divided randomly into three groups; low (L), medium (M), and high (H) dose of dexmedetomidine, that finally 80 cases ended the study and were analyzed. At the end of the surgery, the patients underwent ultrasound-guided TAP block. In all patients of the three groups, the analgesic base of the block was 20 mL bupivacaine 0.125% that was supplemented with 0.5, 1, or 1.5 µ/kg of dexmedetomidine in groups L, M, and H, respectively. Results: The maximum duration of the block was 4 hours in group L and 8 hours in groups M and H. None of the patients needed to receive analgesic at 0, 2, and 24 hours after the block. The dose of analgesic required in the first 8 hours of the block in groups M and H was less than in group L (P < 0.02). Patients in groups H and M were more satisfied with the block (P < 0.01) and experienced less pain compared with group L (P < 0.01). Drowsiness and sedation were observed in patients up to 4 hours after the TAP block, which was dependent on the dexmedetomidine dose (P < 0.01). Conclusions: Based on our results, the optimal dose of supplemental dexmedetomidine could be 1 µ/kg in the TAP block. | en |
| DOI | https://doi.org/10.5812/aapm.113778 | en |
| Keyword | TAP Block | en |
| Keyword | Inguinal Herniorrhaphy | en |
| Keyword | Dexmedetomidine | en |
| Keyword | Bupivacaine | en |
| Keyword | Ultrasound-Guided Nerve Block | en |
| Publisher | Brieflands | en |
| Title | Comparison of Three Different Doses of Dexmedetomidine Added to Bupivacaine in Ultrasound-Guided Transversus Abdominis Plane Block; A Randomized Clinical Trial | en |
| Type | Research Article | en |
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