Effect of Streptokinase immune complex on activation of the complement and interaction with erythrocytes

Abstract

Background: One of major disadvantages of streptokinase, a commonly administered thrombolytic agent, is provocation of hypersensitivity. Objective: To determine interactions of the complement and erythrocytes with streptokinase. Methods: The interactions were studied by the measurement of complement activation products C1S: C1:INH and C3b-P, using modified techniques by Auda et al (1990). The kinetics and dose response of streptokinase immune complexes binding to erythrocytes were studied by flowcytometry. Findings: The findings indicated that the binding of ICs to Es depended significantly on the extent of complement activation (P