Effect of Streptokinase immune complex on activation of the complement and interaction with erythrocytes
| Author | A Afshari | en |
| Author | E Holme | en |
| Issued Date | 1999-12-31 | en |
| Abstract | Background: One of major disadvantages of streptokinase, a commonly administered thrombolytic agent, is provocation of hypersensitivity. Objective: To determine interactions of the complement and erythrocytes with streptokinase. Methods: The interactions were studied by the measurement of complement activation products C1S: C1:INH and C3b-P, using modified techniques by Auda et al (1990). The kinetics and dose response of streptokinase immune complexes binding to erythrocytes were studied by flowcytometry. Findings: The findings indicated that the binding of ICs to Es depended significantly on the extent of complement activation (P | en |
| DOI | https://doi.org/ | en |
| Keyword | Immune complexes (ICs) | en |
| Keyword | Complement | en |
| Keyword | Streptokinase | en |
| Keyword | Erythrocytes (Es) | en |
| Publisher | Brieflands | en |
| Title | Effect of Streptokinase immune complex on activation of the complement and interaction with erythrocytes | en |
| Type | Research Article | en |