The Effectiveness of Cognitive Rehabilitation Based on Computer Tasks on Improving the Cognitive Deficits of Patients with Schizophrenia: A Randomized Controlled Clinical Trial
| Author | Bahareh Hakimi | en |
| Author | Farhad Farid Hosseini | en |
| Author | Farzad Akbarzadeh | en |
| Author | Negar Shamsaki | en |
| Author | Ehsan Abedini | en |
| Author | Zahra Ahmadi | en |
| Orcid | Farzad Akbarzadeh [0000-0003-2898-1560] | en |
| Issued Date | 2025-12-31 | en |
| Abstract | Background: Schizophrenia is one of the most chronic human diseases. Due to the need for the implementation of more effective treatment for cognitive deficits, Objectives: The present study aimed to evaluate the effectiveness of computer-based cognitive rehabilitation in improving cognitive deficits in patients with schizophrenia. Methods: Thirty Patients in the first half of 2021 in patients admitted to Dr. Hejazi and Ibn-e-Sina psychiatric hospitals in the range of 18 - 60 years of age with a diagnosis of schizophrenia, participated in an 8-week randomized controlled clinical trial, for randomization we used randomized block design and for allocation used allocation concealment with closed envelope. The patients randomly divided to two groups: Intervention group, computerized cognitive rehabilitation using Captain Log software was employed, while the control group watched natural movies and play computer games for the same duration as a placebo. Cognitive symptoms were evaluated at baseline and the end of weeks 4, 8, and 12 using various assessments including PANSS, Wisconsin Card Sorting Test, Stroop test, digit span test, and memory tests. Results: In Wisconsin Card Sorting Test, a significant reduction was observed in perseveration errors from 16.40 ± 5.97 to 9.00 ± 4.67 (P < 0.001) in the intervention group in the digit span test, a significant difference was observed in the number of forward digits with the digit sequence initially ascending and then descending from 6.00 ± 1.60 to 7.06 ± 2.18 (P < 0.001). In the Stroop test, incongruent corrects improved significantly from 18.13 ± 11.23 to 29.26 ± 12.00 (P = 0.021), congruent and incongruent errors showed a downward and significant from 5.20 ± 3.68 to 1.93 ± 2.49 and 9.93 ± 9.42 to 3.80 ± 4.55 (P = 0.031, 0.008) and incongruent reaction time improved from 1645.00 ± 121.05 ms to 1438.00 ± 119.60 ms (P = 0.003). In the Ray memory test, the immediate auditory memory item showed a significant upward trend from 3.20 ± 0.86 to 6.33 ± 2.12 (P = 0.017). No significant changes were observed in other domains. Conclusions: These findings suggest computer-based rehabilitation may improve specific cognitive impairments in schizophrenia, warranting further research as an adjunct to standard treatments. | en |
| DOI | https://doi.org/10.5812/semj-160136 | en |
| Keyword | Schizophrenia | en |
| Keyword | Cognitive Deficits | en |
| Keyword | Computer-Based Cognitive Rehabilitation | en |
| Publisher | Brieflands | en |
| Title | The Effectiveness of Cognitive Rehabilitation Based on Computer Tasks on Improving the Cognitive Deficits of Patients with Schizophrenia: A Randomized Controlled Clinical Trial | en |
| Type | Research Article | en |
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