Assessing the Optimal Dose of Mivacurium for Modified Rapid Sequence Intubation in Emergency Surgical Settings: A Randomized, Double-Blind Trial
| Author | Saad Ahmed Moharam | en |
| Author | Ismail Mohamed Abdelgawad Ahmed | en |
| Author | Ahmed Mahmoud Elgarhy | en |
| Author | Sameh Hamdy Abdelhamid Seyam | en |
| Author | Mohammed Talal Almalki | en |
| Author | Mohammed Said ElSharkawy | en |
| Orcid | Saad Ahmed Moharam [0000-0002-1364-4679] | en |
| Orcid | Ismail Mohamed Abdelgawad Ahmed [0000-0001-9636-3946] | en |
| Orcid | Ahmed Mahmoud Elgarhy [0009-0001-6376-8944] | en |
| Orcid | Sameh Hamdy Abdelhamid Seyam [0000-0002-9347-2239] | en |
| Orcid | Mohammed Talal Almalki [0000-0001-6831-803X] | en |
| Orcid | Mohammed Said ElSharkawy [0000-0003-0814-6728] | en |
| Issued Date | 2024-10-31 | en |
| Abstract | Background: Modified rapid sequence intubation (RSI) is crucial in emergency surgery, particularly for patients with a full stomach, as it allows for the administration of general anesthesia (GA). Objectives: This work aimed to evaluate mivacurium effectiveness and optimal dose in modified RSI. Methods: This randomized double-blind study involved 100 patients, aged between 20 - 60 years, of both sexes, with the American Society of Anesthesiologists physical status classification of I - III, who were undergoing emergency surgery under GA. Patients were randomized into two equal groups and received mivacurium in a dose of 0.3 mg/kg in group M1 or 0.4 mg/kg in group muscarinic-2 (M2). Results: Intubating conditions were significantly better in group M2 than in group M1. The onset of adequate muscle relaxation was significantly earlier in group M2 than in group M1 (P < 0.001). At the third minute, mean arterial blood pressure recordings were significantly lower in group M2 (P = 0.04) than in group M1. The recovery time was significantly longer in group M2 than in group M1 (P < 0.001). Conclusions: Mivacurium in a 0.4 mg/kg dose resulted in more favorable intubating conditions during RSI and a more profound, earlier onset of muscle relaxation, but with a longer recovery time compared to the 0.3 mg/kg dose. | en |
| DOI | https://doi.org/10.5812/aapm-153629 | en |
| Keyword | Emergency | en |
| Keyword | Mivacurium | en |
| Keyword | Rapid Sequence Intubation | en |
| Keyword | Dose | en |
| Publisher | Brieflands | en |
| Title | Assessing the Optimal Dose of Mivacurium for Modified Rapid Sequence Intubation in Emergency Surgical Settings: A Randomized, Double-Blind Trial | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- aapm-14-5-153629-publish-pdf.pdf
- Size:
- 443.89 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF