Anti-inflammatory Effects of <i>Avicennia marina</i> on Carrageenan-Induced Paw Edema in Rats
| Author | Ali Asghar Hemmati | en |
| Author | Mohammadamin Eslami Samarin | en |
| Author | Mohammadreza Noveiri | en |
| Author | Fatemeh Kiashi | en |
| Orcid | Ali Asghar Hemmati [0000-0003-2085-8437] | en |
| Orcid | Mohammadamin Eslami Samarin [0009-0005-3245-7915] | en |
| Orcid | Fatemeh Kiashi [0000-0002-5363-3560] | en |
| Issued Date | 2025-08-31 | en |
| Abstract | Background: Inflammation is a protective response to harmful stimuli; however, chronic activation contributes to various diseases. Although NSAIDs are effective, their long-term use is associated with adverse effects. Avicennia marina, a mangrove plant rich in bioactive compounds, has been traditionally used for inflammatory conditions but lacks sufficient experimental validation. Objectives: To investigate the anti-inflammatory effects of a hydroalcoholic extract of A. marina in a carrageenan-induced paw edema model in rats and compare its efficacy with indomethacin. Methods: Thirty male Wistar rats were divided into five groups. Three groups received A. marina extract (200, 400, 600 mg/kg), while controls received indomethacin (10 mg/kg) or saline. Inflammation was induced by subplantar injection of carrageenan (1%, 100 μL). Paw volume was measured over 5 hours. Serum levels of malondialdehyde (MDA) and IL-6 were also assessed. Results: Avicennia marina extract showed a dose-dependent reduction in paw edema, MDA, and IL-6 levels, with 400 mg/kg showing the most consistent reduction across all markers. Although indomethacin showed greater efficacy, the extract demonstrated significant anti-inflammatory activity. Conclusions: Avicennia marina extract at 400 mg/kg shows the most favorable profile, attenuating acute inflammation in rats and may serve as a potential plant-based alternative to NSAIDs. | en |
| DOI | https://doi.org/10.5812/jjnpp-159071 | en |
| Keyword | Anti-inflammatory | en |
| Keyword | <i>Avicennia marina</i> | en |
| Keyword | Carrageenan | en |
| Keyword | Oxidative Stress | en |
| Keyword | Inflammation | en |
| Publisher | Brieflands | en |
| Title | Anti-inflammatory Effects of <i>Avicennia marina</i> on Carrageenan-Induced Paw Edema in Rats | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- jjnpp-20-3-159071-publish-pdf.pdf
- Size:
- 714.06 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF