Improvement of Antiproliferative Activity of Recombinant Truncated Form of Pseudomonas aeruginosa Exotoxin (PE38) by Vitamin E in MCF-7 Cells
| Author | Vahid Asgary | en |
| Author | Razieh Bigdeli | en |
| Author | Fahimeh Baghbani-Arani | en |
| Author | Atieh Hashemi | en |
| Orcid | Atieh Hashemi [0000-0001-7121-5306] | en |
| Issued Date | 2020-06-30 | en |
| Abstract | Background: In addition to beneficial roles of vitamin E in many metabolic processes and its antitumor activities, vitamin E derivatives have extensively been considered as permeability enhancers. Using these enhancers, permeability of a wide spectrum of drugs was reported to be significantly increased. PE38, a toxic substance with a potential application in cancer therapy, is a truncated form of Pseudomonas exotoxin A (PE), which lacks Ia and a portion of domain Ib. Objective: Here, the antiproliferative potential of PE38 and alpha-tocopherol (αT) form of vitamin E were assessed in MCF-7 cells. The role of vitamin E in PE38 cytotoxicity level was also evaluated. Materials and Methods: The antiproliferative potential of PE38, vitamin E, and a combination of them were colorimetrically evaluated in a cellular breast cancer model (MCF-7), using the MTT assay. P values of | en |
| DOI | https://doi.org/10.4103/jrptps.JRPTPS_114_19 | en |
| Keyword | Antiproliferative activity | en |
| Keyword | MCF-7 cells | en |
| Keyword | MTT | en |
| Keyword | PE38 | en |
| Keyword | vitamin E | en |
| Publisher | Brieflands | en |
| Title | Improvement of Antiproliferative Activity of Recombinant Truncated Form of Pseudomonas aeruginosa Exotoxin (PE38) by Vitamin E in MCF-7 Cells | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- improvement_of_antiproliferative_activity_of.6.pdf
- Size:
- 784.61 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF