Comparing the Efficacy of 8 Weeks Treatment of Cipram® and its Generic Citalopram in Patients With Mixed Anxiety-Depressive Disorder
| Author | Hasan Khoonsari | en |
| Author | Mohammad Bagher Oghazian | en |
| Author | Mona Kargar | en |
| Author | Mahdiyeh Moin | en |
| Author | Hossein Khalili | en |
| Author | Abbas Alimadadi | en |
| Author | Hassan Torkamandi | en |
| Author | Padideh Ghaeli | en |
| Issued Date | 2015-06-28 | en |
| Abstract | Background:: Patients with mixed anxiety-depressive disorder (MADD) suffer both anxiety and depression. Antidepressants, especially, selective serotonin reuptake inhibitors are among agents of choice for treating this condition. Objectives:: This study compared the efficacy of Cipram® with its generic, citalopram. Patients and Methods:: Forty adult outpatients (between 18 to 55 years of age) with a diagnosis of MADD who met the trial criteria, entered this double-blind, randomized study. Subjects were assigned to receive either generic citalopram or Cipram® for 8 weeks. Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) were utilized to assess depression and anxiety at baseline, weeks 4 and 8 of the study. Statistical analysis was performed using SPSS 14.0. Results:: Twenty patients received citalopram (mean dosages of 22 mg/day during the first 4 weeks and 33 mg/day during weeks 4 to 8) and 20 received Cipram® (mean dosages of 22 mg/day during the first 4 weeks and 29 mg/day during weeks 4 to 8). Both treatments were noted to be effective in improving the symptoms of MADD at weeks 4 and 8. The mean differences of HAM-D and HAM-A between Citalopram and Cipram® groups were significantly different at the end of week 4 (HAM-D: P = 0.038, HAM-A: P = 0.025), but not at the end of week 8 (HAM-D: P = 0.239, HAM-A: P = 0.204). Both medications were tolerated well by the patients. Conclusions:: This study suggests that the efficacy of citalopram is similar to that of Cipram® in the treatment of MADD after 8 weeks. Meanwhile, Cipram® may reduce depression and anxiety quicker than its generic, citalopram. | en |
| DOI | https://doi.org/10.17795/ijpbs230 | en |
| Keyword | Citalopram | en |
| Keyword | Anxiety | en |
| Keyword | Depressive Disorder | en |
| Keyword | Serotonin Uptake Inhibitors | en |
| Publisher | Brieflands | en |
| Title | Comparing the Efficacy of 8 Weeks Treatment of Cipram® and its Generic Citalopram in Patients With Mixed Anxiety-Depressive Disorder | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijpbs-09-230.pdf
- Size:
- 129.01 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF