Assessment of proportional hazard rate of endocrine disease in major beta-thalassemia in Shiraz 2005-2006

Abstract

Background: Thalassemia is the most common hemolytic anemia in Iran and around the world that needs regular blood transfusion. Transfusion leads to iron overload in the body. Absence or irregular chelation therapy in these patients leads to various complications such as cardiac diseases, endocrine disorders and infectious diseases like HIV and hepatitis. The purpose of this study was to evaluate the hazard rate of endocrine disease and related factors using COX model. Materials and Methods: This cross-sectional study was carried out on eight-hundred and six thalassemic (406 male and 400 female) patients referring to Cooley’s ward of Dastgheib hospital in Shiraz who were studied using a structured questionnaire through enumeration method. Age of occurrence, demographic information, age of onset and type of transfusion, and age of onset and method of chelation therapy were specified. Specialist physicians diagnosed the complications. Data were analyzed using descriptive and analytical (Proportional hazard rate and its confidence interval using COX model) statistical. Results: The range of the subject’s age was between 1- 43 years and mean age ± SD was 15.34±6.82 years. The prevalence rate of hypogonadism, hypothyroidism, hyperparathyroidism and diabetes mellitus was 14.5%, 2.4%, 6.9% and 7.5% respectively and the mean age of onset of hypogonadism, hypothyroidism, hypoparathyroidism and diabetes mellitus was 18.42±3.6, 15.83±3.5, 16.98 ± 4.5 and 17.19 ± 4.8 respectively. There was a significant association between proportional hazard rate of all complications and age of chelation therapy onset (P