Effects of Concentrated Pomegranate Juice on Subclinical Inflammation and Cardiometabolic Risk Factors for Type 2 Diabetes: A Quasi-Experimental Study
| Author | Farideh Shishehbor | en |
| Author | Majid Mohammad shahi | en |
| Author | Mehdi Zarei | en |
| Author | Azadeh Saki | en |
| Author | Mehrnoosh Zakerkish | en |
| Author | Fatemeh Shirani | en |
| Author | Maryam Zare | en |
| Issued Date | 2016-01-01 | en |
| Abstract | Background: The health benefits of pomegranate juice have been reported in several studies. However, limited clinical trials have examined the effects of concentrated pomegranate juice (CPJ) on inflammatory factors. Objectives: This study aimed to investigate the effects of CPJ on metabolic risk factors, including inflammatory biomarkers, in patients with type 2 diabetes mellitus. Patients and Methods: In a quasi-experiment trial, 40 type 2 diabetic patients were asked to consume 50 g of CPJ daily for 4 weeks. Anthropometric indices, dietary intake, blood pressure measurements, and fasting blood samples were conducted at baseline and 4 weeks after the intervention. Results: The intake of CPJ produced a significant increase in both total and high-density lipoprotein cholesterol (HDL-C) (4.7% and 3.9%, respectively) from baseline (P < 0.05). However, changes that were observed in serum triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose, and blood pressure were not statistically significant. Administration of CPJ caused significant reduction in serum interleukin-6 (IL-6) (P < 0.05), but tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP) remained unchanged during the study. The mean value of serum total antioxidant capacity (TAC) was substantially increased (~ 75%) from 381.88 ± 114.4 at baseline to 1501 ± 817 after 4 weeks of CPJ consumption. Conclusions: Consumption of CPJ (50 g/day) appears to have favorable effects on some markers of subclinical inflammation, and to increase plasma concentrations of antioxidants in patients with type 2 diabetes. | en |
| DOI | https://doi.org/10.5812/ijem.33835 | en |
| Keyword | Concentrated Pomegranate Juice | en |
| Keyword | TNF-α | en |
| Keyword | IL-6 | en |
| Keyword | TAC | en |
| Keyword | LDL-C | en |
| Keyword | HDL-C | en |
| Keyword | type 2 Diabetes | en |
| Keyword | hs-CRP | en |
| Publisher | Brieflands | en |
| Title | Effects of Concentrated Pomegranate Juice on Subclinical Inflammation and Cardiometabolic Risk Factors for Type 2 Diabetes: A Quasi-Experimental Study | en |
| Type | Research Article | en |
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