Postchemotherapy Retroperitoneal Lymph Node Dissection in Patients With Nonseminomatous Testicular Cancer: A Single Center Experiences
| Author | Mohamadreza Nowroozi | en |
| Author | Mohsen Ayati | en |
| Author | Amir Arbab | en |
| Author | Hassan Jamshidian | en |
| Author | Hamidreza Ghorbani | en |
| Author | Hassan Niroomand | en |
| Author | Mohsen Taheri Mahmoodi | en |
| Author | Erfan Amini | en |
| Author | Sohrab Salehi | en |
| Author | Hamid Hakima | en |
| Author | Farid Fazeli | en |
| Author | Saeid Haghdani | en |
| Author | Alireza Ghadian | en |
| Issued Date | 2015-09-01 | en |
| Abstract | Background: Testicular cancer accounts for about 1 - 1.5% of all malignancies in men. Radical orchiectomy is curative in 75% of patients with stage I disease, but advance stage with retroperitoneal lymph node involvement needs chemotherapy. All patients who have residual masses ≥ 1 cm after chemotherapy should undergo postchemotherapy retroperitoneal lymph node dissection (PC-RPLND). Objectives: Treatment of advanced nonseminomatous testicular cancer is usually a combination of chemotherapy and surgery. We described our experience about postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) in our center. Patients and Methods: In a retrospective cross-sectional study between 2006 and 2011, patients with a history of postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) in Imam Khomeini hospital were evaluated. All patients had normal postchemotherapy serum tumor markers and primary nonseminomatous cancer. We reviewed retrospectively clinical, pathological, and surgical parameters associated with PC-RPLND in our center. Results: Twenty-one patients underwent bilateral PC-RPLND. Mean age was 26.3 years (ranged 16 - 47). Mean size of retroperitoneal mass after chemotherapy was 7.6 cm. Mean operative time was 198 minutes (120 - 246 minutes). Mean follow-up time was 38.6 months. Pathologic review showed presence of fibrosis/necrosis, viable germ cell tumor and teratoma in 8 (38.1%), 10 (47.6%) and 3 (14.28%) patients, respectively. One patient in postoperative period of surgery and three patients in two first years after surgery were expired. Of 17 alive patients, only two (11.8%) had not retrograde ejaculation. Conclusions: PC-RPLND is one the major operations in the field of urology, which is associated with significant adjunctive surgeries. In appropriate cases, PC-RPLND was associated with good cancer specific survival in tertiary oncology center. | en |
| DOI | https://doi.org/10.5812/numonthly.27343 | en |
| Keyword | Teratoma | en |
| Keyword | Germ Cell Tumor | en |
| Keyword | Tumor | en |
| Publisher | Brieflands | en |
| Title | Postchemotherapy Retroperitoneal Lymph Node Dissection in Patients With Nonseminomatous Testicular Cancer: A Single Center Experiences | en |
| Type | Research Article | en |
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