Investigating the Role of Gummosin in Improving Memory in the Scopolamine Damaged Memory Model for the Possible NMDA-CREB-Ca⁺² Pathway

Abstract

Background: The present study investigates the effects of gummosin on memory impairment after scopolamine injection Methods: A total of 65 male Wistar rats were randomly divided into 5 groups of 13. Scopolamine was used to induce memory and learning impairments. In the present study, the effects of gummosin on memory enhancement were examined using the passive avoidance learning behavioral test, Morris water maze behavioral test, and open field test. Results: In the rat model of memory impairment, the administration of gummosin at a dose of 20 in the scopolamine + gummosin 20 group improved spatial learning performance in the Morris water maze test. Conclusions: Our study results demonstrated that gummosin, in a dose-dependent manner, improved memory and learning in behavioral and electrophysiological tests, accompanied by increased expression of NR2A and CREB genes and decreased expression of NR2B gene.