Investigation of protein network of proteins in cardiovascular disease

Abstract

Introduction: Cardiovascular disease (CVD) that involved heart and vessels of heart, is one of the most common reasons of death in the world and unfortunately there are limitations in early diagnosis of this disease. In this study it has been survived the protein-protein interaction network in order to discover special biomarkers for early diagnosis of disease and timely treatment. Materials and Methods: In this study, involved proteins in cardiovascular disease have been collected using OMIM, Poly search and Wiki pathway databases and then these proteins have been matched on protein-protein interaction network. Topological analysis of network has been done with Cytoscape 3.3.Meaningly, degree and betweeness parameters have been considered to introduce the candidate markers. Results: After network topological analysis, proteins with higher degree have been recognized as hub and proteins with higher betweenness as bottleneck. It has been introduced 3 hub-bottleneck proteins as candidate biomarkers which have high centrality in network. Conclusion: MMP9, IL6 and AKT1 have been introduced as candidate proteins for CVD which can be diagnostic biomarkers or drug targets for this disease. In addition to, biochemical pathways for proteins in highest score sub-network were negative regulation of ion transport, collagen biosynthetic process, platelete degradation and extra cellular matrix disassembly