99mTc-IgG-Lung Scintigraphy in the Assessment of Pulmonary Involvement in Interstitial Lung Disease and Its Comparison With Pulmonary Function Tests and High-Resolution Computed Tomography: A Preliminary Study
| Author | Mehrzad Bahtouee | en |
| Author | Jamshid Saberifard | en |
| Author | Hamid Javadi | en |
| Author | Iraj Nabipour | en |
| Author | Hasan Malakizadeh | en |
| Author | Gholamhossein Monavvarsadegh | en |
| Author | Hoda Ilkhani Pak | en |
| Author | Azadeh Sadeghi | en |
| Author | Majid Assadi | en |
| Issued Date | 2015-10-01 | en |
| Abstract | Background: The discrimination of inactive inflammatory processes from the active form of the disease is of great importance in the management of interstitial lung disease (ILD). Objectives: The aim of this study was to determine the efficacy of 99mTc-IgG scan for the detection of severity of disease compared to high-resolution computed tomography (HRCT) and pulmonary function test (PFT). Patients and Methods: Eight known cases of ILD including four cases of Mustard gas (MG) intoxication and four patients with ILD of unknown cause were included in this study. A population of six patients without lung disease was considered as the control group. The patients underwent PFT and high-resolution computed tomography, followed by 99mTc-IgG scan. They were followed up for one year. 99mTc-IgG scan assessment of IgG uptake was accomplished both qualitatively (subjectively) and semiquantitatively. Results: All eight ILD patients demonstrated a strong increase in 99mTc-IgG uptake in the lungs, compared to the control patients. The 99mTc-IgG scan scores were higher in the patient group (0.64[95% confidence interval(CI)=0.61-0.69])) than the control group (0.35 (0.35[95% CI=0.28-0.40]), (P 0.05). There were no significant correlations between 99mTc-IgG score and HRCT patterns including ground glass opacity, reticular fibrosis and honeycombing (P value > 0.05). Conclusion: The present results confirmed that 99mTc-IgG scan could be applied to detect the severity of pulmonary involvement, which was well correlated with HRCT findings. This data also showed that the 99mTc-IgG scan might be used as a complement to HRCT in the functional evaluation of the clinical status in ILD; however, further studies are recommended. | en |
| DOI | https://doi.org/10.5812/iranjradiol.14619v2 | en |
| Keyword | Interstitial Lung Disease | en |
| Keyword | Tomography | en |
| Keyword | X-Ray Computed | en |
| Keyword | Respiratory Function Tests | en |
| Keyword | Mustard Gas | en |
| Publisher | Brieflands | en |
| Title | 99mTc-IgG-Lung Scintigraphy in the Assessment of Pulmonary Involvement in Interstitial Lung Disease and Its Comparison With Pulmonary Function Tests and High-Resolution Computed Tomography: A Preliminary Study | en |
| Type | Brief Report | en |
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