A Comparison of Dexmedetomidine and Magnesium Sulfate as an Anesthetic Adjuvant in Trans-Sphenoidal Pituitary Surgery

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AuthorMasoud Nashibien
AuthorParisa Sezarien
AuthorSara Nashibien
AuthorNina Pilevaren
AuthorFarhad Safarien
AuthorSeyyed-Sam-Mehdi Hosseininasaben
AuthorSogol Asgarien
OrcidMasoud Nashibi [0000-0003-3825-9889]en
OrcidParisa Sezari [0000-0003-3874-1050]en
OrcidSara Nashibi [0000-0002-8556-7211]en
OrcidNina Pilevar [0000-0002-6495-4423]en
OrcidFarhad Safari [0000-0002-1479-8477]en
OrcidSeyyed-Sam-Mehdi Hosseininasab [0009-0008-7775-6443]en
OrcidSogol Asgari [0000-0001-7837-8888]en
Issued Date2024-12-31en
AbstractBackground: Trans-sphenoidal pituitary surgery is a minimally invasive procedure used for pituitary disorders. Objectives: This study aims to investigate the effects of dexmedetomidine and magnesium sulfate in improving anaesthesia conditions and pain control during trans-sphenoidal pituitary surgery. Methods: This prospective randomised clinical trial included 90 patients between 18 and 65 years of age, with American Society of Anaesthesiologists (ASA) physical status I and II, who were undergoing elective trans-sphenoidal pituitary surgery. Exclusion criteria included a change in surgical technique during surgery and patients who were transferred directly to the ICU with a tracheal tube. Patients were randomly assigned to three groups (group D: Dexmedetomidine, group M: Magnesium sulfate, and group C: Control), and various parameters such as haemodynamics, surgical field evaluation, and pain were assessed. Results: Ninety consecutive patients were included in this study. Forty-seven males (52.2%) and 43 females (47.8%) were evaluated. There were no significant differences among the three groups regarding gender distribution, age, or Body Mass Index (BMI). The mean age of the included patients was 46.27 ± 12.47 years. The measured mean arterial pressure was lower in group D compared to group M (P-value = 0.005). The other variable that statistically differed between the two groups was the numerical rating scale, which was lower in group D (P-value = 0.02). All measured variables in group D and group M were significantly lower compared to the control group, except for the extubation time. Conclusions: Adding dexmedetomidine as an adjuvant anaesthetic medication during trans-sphenoidal pituitary surgery could potentially enhance haemodynamic stability and improve surgeon satisfaction scores.en
DOIhttps://doi.org/10.5812/jcma-149422en
KeywordDexmedetomidineen
KeywordMagnesium Sulfateen
KeywordTrans-Sphenoidal Pituitary Surgeryen
KeywordAnesthesiaen
PublisherBrieflandsen
TitleA Comparison of Dexmedetomidine and Magnesium Sulfate as an Anesthetic Adjuvant in Trans-Sphenoidal Pituitary Surgeryen
TypeResearch Articleen

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Journal of Cellular & Molecular Anesthesia