Using Montelukast as an Add-on Treatment in Nephrotic Syndrome of Pediatrics: A Randomized Clinical Trial Study
| Author | Fatemeh Javidi | en |
| Author | Parsa Yousefichaijan | en |
| Author | Fatemeh Dorreh | en |
| Author | Ali Arjmand | en |
| Author | Masoud Rezagholizamenjany | en |
| Orcid | Parsa Yousefichaijan [0000-0002-6243-431X] | en |
| Orcid | Masoud Rezagholizamenjany [0000-0002-5824-2366] | en |
| Issued Date | 2021-11-30 | en |
| Abstract | Background: Montelukast, as a non-steroidal anti-inflammatory drug, could reduce inflammation in nephrotic syndrome (NS). This study aimed to evaluate the therapeutic effect of montelukast as adjunctive agent in pediatric NS. Methods: This clinical trial study was conducted on patients with NS. The patients were assigned into two equal groups (N = 25 in each) of intervention (steroid + montelukast) and control and treated for one month. One month later, in the follow-up stage, their proteinuria was measured. The results before and after treatment were statistically analyzed by SPSS software version 21, and the final report of the project was presented. Results: The age of participants in the intervention and control groups was 7.26 ± 4.23 and 6.79 ± 3.91 years, respectively (P = 0.68), and there were 10 female participants in both groups (P = 1.0). Albumin levels in 96% of the control group and 76% of the intervention group were 1.5 - 2.5 μg/dL (P = 0.037). Also, 48% of participants in the control group were corticosteroid dependent, and 60% of participants in the intervention group responded to corticosteroids (P = 0.194). The severity of nephrotic syndrome was moderate in 60% of participants in the control group and mild in 60% of participants in the intervention group (P = 0.138). Conclusions: The results of present study showed that recovery rate was higher in the intervention group, but the difference was not statistically significant. | en |
| DOI | https://doi.org/10.5812/numonthly.116375 | en |
| Keyword | Nephrotic Syndrome | en |
| Keyword | Pediatric | en |
| Keyword | Montelukast | en |
| Publisher | Brieflands | en |
| Title | Using Montelukast as an Add-on Treatment in Nephrotic Syndrome of Pediatrics: A Randomized Clinical Trial Study | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- num-13-4-116375.pdf
- Size:
- 124.47 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF