Use of Remifentanil and Alfentanil in Endotracheal Intubation: A Comparative Study
| Author | Farnad Imani | en |
| Author | Mahmoud-Reza Alebouyeh | en |
| Author | Zahra Taghipour Anvari | en |
| Author | Seyyed Hamid Reza Faiz | en |
| Issued Date | 2011-12-31 | en |
| Abstract | Background: Opioids, such as alfentanil, are used to facilitate endotracheal intubation without the use of neuromuscular blocking agents in patients undergoing elective surgery. Objectives: The goal of this study was to evaluate the endotracheal intubation conditions when remifentanil or alfentanil was used with propofol without the application of neuromuscular blocking agents. Patients and Methods: One hundred American Society of Anesthesiologists (ASA) grade I patients scheduled for elective surgery were enrolled in this prospective, randomized, triple-blinded study. The patients were randomized to group A (alfentanil) or R (remifentanil). In group A, alfentanil (50 mcg/kg) was intravenously injected over 10 seconds, and after 45 seconds or at the occurrence of apnea, propofol (2 mg/kg) was intravenously injected over 5 seconds. Thirty seconds after the administration of propofol, laryngoscopy and endotracheal intubation were attempted. In group R, remifentanil (5 mcg/kg) was administered instead of alfentanil. Intubation conditions, including ease of laryngoscopy, patency of the vocal cords, jaw relaxation, limb movement (1-4 score), and also, demographic data were evaluated. Results: There were no demographic data differences between groups (age, weight, and sex). Further, laryngoscopy, jaw relaxation, and limb movement scores were similar in the R and A groups and there were no significant differences, but vocal cords were significantly more patent in group R than those in group A (P = 0. 028). Conclusions: The results of this study showed that remifentanil, similar to alfentanil, provided excellent conditions for endotracheal intubation when used with propofol for the induction of anesthesia; however, remifentanil improved the patency of the vocal cords to a greater extent than alfentanil. | en |
| DOI | https://doi.org/10.5812/kowsar.22287523.2130 | en |
| Keyword | Alfentanil | en |
| Keyword | Remifentanil | en |
| Keyword | Propofol | en |
| Keyword | Endotracheal intubation | en |
| Publisher | Brieflands | en |
| Title | Use of Remifentanil and Alfentanil in Endotracheal Intubation: A Comparative Study | en |
| Type | Research Article | en |