The effect of fish oil on two-step tuberculin test in hospitalized patients: A randomized controlled trial
| Author | N Arfa | en |
| Author | Abbas Allami | en |
| Orcid | Abbas Allami [0000-0003-4047-8183] | en |
| Issued Date | 2018-03-31 | en |
| Abstract | Background: According to national tuberculosis control guide, two-step tuberculin skin test (TST) should be done in the elderly, if the initial test is negative. However, it raises questions about the usefulness of this approach. Objective: This study aimed to explore the effects of fish oil supplements on the two-step tuberculin test in hospitalized patients. Methods: In this randomized controlled clinical trial, 128 patients randomly allocated to control group (receiving placebo, n=64) and treatment group (receiving fish oil supplements, n=64) during 2016. Fish oil supplement group was treated with 2 g daily for 4 consecutive days. The outcome was considered a change in 2 sequential TST induration sizes. Significant increase in the size of the secondary induration compared to primary was considered 6 mm or more. Findings: There was significant difference between primary and secondary indurations of two groups (higher in treatment group) (P=0.04). According to the results of analysis of variance and correlation tests, two effective factors were identified: initial induration and residence location (P=0.014 and P=0.002, respectively). In both groups, no clinically significant increase in the size of induration was observed. Conclusion: It seems that the number of cases considered as infected with tuberculosis does not increase with two- rather than one-step tuberculin skin test. Also, the short-term administration of fish oil supplements does not change this result. | en |
| DOI | https://doi.org/ | en |
| Keyword | Fish oils | en |
| Keyword | Polyunsaturated fatty acids | en |
| Keyword | Dietary supplements | en |
| Keyword | Tuberculin test | en |
| Keyword | Clinical trial | en |
| Publisher | Brieflands | en |
| Title | The effect of fish oil on two-step tuberculin test in hospitalized patients: A randomized controlled trial | en |
| Type | Research Article | en |
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