Evaluation of the Relationship between Prostate Cancer and Serum ?nflammation Markers

Abstract

Background and Aims: In this study, we aimed to examine whether there is a relationship between the serum inflammation markers C-Reactive Protein (CRP), Lactate Dehydrogenase (LDH), erythrocyte sedimantation rate (ESR), ceruloplasmin; and stage of prostate cancer (Pca), serum prostate specific antigen (PSA) level and Gleason score in prostate cancer(Pca) patients. Methods: Fourtyone patients diagnosed as prostate cancer, and 46 patients forming the control group, and diagnosed as benign prostatic hyperplasia (BPH) were included in this study. The prostate cancer group was divided into subgroups according to the following parameters; PSA ≤20 ng/mL and >20 ng/mL, Gleason scores of ≤6 and >6, and further the cases with and without bone metastasis. Results: It was detected that serum levels of CRP, ceruloplasmin and ESR were significantly higher in prostate cancer group, compared with the control group (p6 compared with the Pca patients Gleason score ≤6 (p20 ng/mL, compared with the ones with serum PSA levels≤20 ng/mL in the Pca group, as well (p